Reaktion #439548

Reaktionsgleichung

5-fluoroindoline

1-acetyl-6-bromo-5-fluoroindoline

cis-3,5-dimethylpiperazine

→

title compound

cis-5-Fluoro-6-(3,4,5-trimethylpiperazin-1-yl)indoline

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was isolated as a pale yellow solid

Vorschrift

The title compound was prepared from 1-acetyl-6-bromo-5-fluoroindoline (prepared by bromination of 5-fluoroindoline analogous to procedure in J. Het. Chem. 1983, 20, 349, followed by N-acylation) by reaction with cis-3,5-dimethylpiperazine using similar procedure to Description 2 (82%), followed by N-methylation using procedure similar to Description 24 (69%), followed by hydrolysis as in Description 3 (96%). The product was isolated as a pale yellow solid.

Quelle