Reaktion #43926

Reaktionsgleichung

4-bromo-3,5-dimethylphenol

acetic anhydride

→

title compound

Ausbeute 128.9%

4-bromo-3,5-dimethylphenyl acetate

Ausbeute 128.9%

Lösungsmittel

hydrochloric acid

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled
2. 2
   Extraktionextracted with ethyl acetate
3. 3
   WaschenThe extract was washed with saturated brine
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   Einengenconcentrated under reduced pressure

Vorschrift

To a solution of 4-bromo-3,5-dimethylphenol (10.1 g, 50.0 mmol) in pyridine (13 mL) was added acetic anhydride (7.66 g, 38.6 mmol), and the mixture was stirred at 50° C. for 30 min. The reaction mixture was ice-cooled, diluted with 0.5 M hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (12.1 g, yield 99%) as a yellow oil.

Quelle