Reaktion #43923

Reaktionsgleichung

ethyl 4-chloroacetoacetate

resorcinol

→

title compound

Ausbeute 84.0%

4-(chloromethyl)-7-hydroxy-2H-chromen-2-one

Ausbeute 84.0%

Lösungsmittel

sulfuric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturUnder ice-cooling
2. 2
   Filtrationthe precipitated solid was collected by filtration
3. 3
   Waschenwashed with water
4. 4
   Sonstigeair-dried

Vorschrift

Under ice-cooling, ethyl 4-chloroacetoacetate (14.0 g, 85.0 mmol) was dissolved in concentrated sulfuric acid (30 mL), resorcinol (8.81 g, 80.0 mmol) was added by small portions, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was poured into ice water, and the precipitated solid was collected by filtration, washed with water, and air-dried to give the title compound (14.1 g, yield 84%) as a beige powder.

Quelle