Reaktion #439187

Reaktionsgleichung

4-hydroxy-5,6-dimethyl-2(1H)-pyridone

nitric acid

→

2,4-Dihydroxy-5,6-dimethyl-3-nitropyridine

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling the mixture in an ice bath
2. 2
   Temperaturafter refluxing
3. 3
   Filtrationto filtration

Vorschrift

The above nitration process was essentially repeated using 23.612 g 4-hydroxy-5,6-dimethyl-2(1H)-pyridone, 460 ml acetic acid, 12.2 ml nitric acid, and cooling the mixture in an ice bath after refluxing and prior to filtration. Combined product was used in the next step.

Quelle