Reaktion #4390

Reaktionsgleichung

2-amino-3-chloropyrazine

2-methylbenzylamine

potassium carbonate

potassium iodide

→

2-amino-3-(2-methylbenzylamino)pyrazine

Ausbeute 19.7%

Lösungsmittel

water

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 24 hours under a nitrogen atmosphere
2. 2
   Sonstigeto stand at room temperature
3. 3
   Extraktionextracted with ethyl acetate
4. 4
   WaschenThe extract was washed with water
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Sonstigeevaporated in vacuo
7. 7
   SonstigeThe residue was purified by column chromatography on silica gel (110 g) with a mixture of chloroform and methanol (100:3) as an eluent

Vorschrift

A mixture of 2-amino-3-chloropyrazine (4.3 g), 2-methylbenzylamine (4.6 g), potassium carbonate (5.5 g), and potassium iodide (0.4 g) in N,N-dimethylformamide (43 ml) was refluxed for 24 hours under a nitrogen atmosphere and allowed to stand at room temperature. The mixture was poured into water and extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate, and evaporated in vacuo. The residue was purified by column chromatography on silica gel (110 g) with a mixture of chloroform and methanol (100:3) as an eluent to give 2-amino-3-(2-methylbenzylamino)pyrazine (1.4 g).

Quelle