Reaktion #438830

Reaktionsgleichung

1-tert-butoxycarbonyl-4-acetyl-piperidine

2-amino-3-formyl-pyridine

L-proline

→

title compound

Ausbeute 24.9%

4-([1,8]Naphthyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

Ausbeute 24.9%

Lösungsmittel

n-butanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter removing the solvent in vacuo the residue
2. 2
   Sonstigeobtained in an identical reaction
3. 3
   Sonstigechromatographed on silica gel with ethyl acetate/n-heptane (1:1)

Vorschrift

3.14 g of 1-tert-butoxycarbonyl-4-acetyl-piperidine and 1.83 g of 2-amino-3-formyl-pyridine were refluxed with 0.25 g of L-proline in n-butanol for 72 hours. After removing the solvent in vacuo the residue was combined with the residue obtained in an identical reaction and chromatographed on silica gel with ethyl acetate/n-heptane (1:1) to give 1.08 g of the title compound.

Quelle