Reaktion #438786

ord-3aa8f6b7a1f74f9e87d81b68d2fd526c

Reaktionsgleichung

CC(C)(C)OC(=O)C1Cn2ccc3c(CC(N)=O)ccc(c32)CN1
7-Carbamoylmethyl-3,4-dihydro-1H-[1,4]diazepino[6,7,1-hi]indole-2-carboxylic acid tert-butyl ester
COC(=O)C(=O)c1cn2c3c(cccc13)CC(C)(C)C2
(5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-oxo-acetic acid methyl ester
→
CC1(C)Cc2cccc3c(C4=C(c5ccc6c7c5ccn7CC(C(=O)OC(C)(C)C)NC6)C(=O)NC4=O)cn(c23)C1
title compound
CC1(C)Cc2cccc3c(C4=C(c5ccc6c7c5ccn7CC(C(=O)OC(C)(C)C)NC6)C(=O)NC4=O)cn(c23)C1
7-[4-(5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-3,4-dihydro-1H-[1,4]diazepino[6,7,1-hi]indole-2-carboxylic acid tert-butyl ester

Edukte

CC(C)(C)OC(=O)C1Cn2ccc3c(CC(N)=O)ccc(c32)CN1
7-Carbamoylmethyl-3,4-dihydro-1H-[1,4]diazepino[6,7,1-hi]indole-2-carboxylic acid tert-butyl ester
COC(=O)C(=O)c1cn2c3c(cccc13)CC(C)(C)C2
(5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-oxo-acetic acid methyl ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Beginning with 7-Carbamoylmethyl-3,4-dihydro-1H-[1,4]diazepino[6,7,1-hi]indole-2-carboxylic acid tert-butyl ester and (5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-oxo-acetic acid methyl ester, the title compound was prepared essentially as described in Example 1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06743785B2uspto-grants-2004_06