Reaktion #43865

Reaktionsgleichung

[5-(Benzyl-cyclohexanecarbonyl-amino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

TFA

→

title compound

[5-(Benzyl-cyclohexanecarbonyl-amino)-2-propyl-benzoimidazol 1-yl]-acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated
2. 2
   Sonstigepurified by preparative LCMS

Vorschrift

[5-(Benzyl-cyclohexanecarbonyl-amino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (0.12 mmol) was treated with TFA (2 mL) for 2 hours, concentrated, and purified by preparative LCMS to give the title compound. 1H NMR (d6-DMSO) δ7.50 (d, 1H), 7.21 (m, 6H), 6.95 (m, 1H), 5.09 (s, 2H), 4.86 (s, 2H), 2.72 (t, 2H), 2.18 (m, 1H), 1.60 (m, 9H), 1.10 (m, 1H), 0.99 (t, 3H), 0.85 (m, 2H). MS calculated for C26H31N3O3+H: 434, observed: 434.

Quelle