Reaktion #438505

Reaktionsgleichung

methyl acrylate

hexanol

N-hydroxyphthalimide

acetonitrile

oxygen

→

α-hydroxy-γ-pentyl-γ-butyrolactone

ethyl β-hexanoyl-α-hydroxypropionate

Reaktionsbedingungen

Vorschrift

A mixture of 3 mmol of methyl acrylate, 30 mmol of hexanol, 0.6 mmol of N-hydroxyphthalimide, 0.003 mmol of cobalt(II) acetate, 0.03 mmol of acetylacetonatocobalt(III), and 1 ml of acetonitrile was stirred at 60° C. in an oxygen atmosphere (1 atm) for 5 hours. A reaction mixture was subjected to column chromatography on a silica gel to yield α-hydroxy-γ-pentyl-γ-butyrolactone in a yield of 46% and ethyl β-hexanoyl-α-hydroxypropionate in a yield of 40%.

Quelle