Reaktion #43826

Reaktionsgleichung

2,3-Dichlorobenzyl chloride

K2CO3

[5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

→

{5-[(2,3-Dichloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-l-yl}-acetic acid tert-butyl ester

Lösungsmittel

EtOAc

H2O

CH3CN

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered through an Extrelut column
2. 2
   WaschenThe column was washed with EtOAc
3. 3
   Einengenthe filtrate was concentrated
4. 4
   SonstigeThe crude product was carried onto the next reaction without any further purification or characterization

Vorschrift

2,3-Dichlorobenzyl chloride (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.

Quelle