Reaktion #43812

ord-7127dda99fa6496f990591c54edd8f2f

Reaktionsgleichung

CCCc1nc2cc(NC(=O)OC(C)(C)C)ccc2n1CC(=O)OC(C)(C)C
product
CCCc1nc2cc(NC(=O)OC(C)(C)C)ccc2n1CC(=O)OC(C)(C)C
(5-tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester
→
CCCc1nc2cc(N)ccc2n1CC(=O)OC(C)(C)C
sub-title compound
CCCc1nc2cc(N)ccc2n1CC(=O)OC(C)(C)C
(5-Amino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

Edukte

CCCc1nc2cc(NC(=O)OC(C)(C)C)ccc2n1CC(=O)OC(C)(C)C
product
CCCc1nc2cc(NC(=O)OC(C)(C)C)ccc2n1CC(=O)OC(C)(C)C
(5-tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

Reagenzien

Keine

Lösungsmittel

Cl
HCl
C1COCCO1
dioxane

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    EinengenThe reaction was concentrated

Vorschrift

The product of example 25, step d.) (140 mg, 0.359 mmol) was stirred in 4 M HCl in dioxane (1 mL) at ambient temperature for an hour. The reaction was concentrated to give the sub-title compound that was used in crude form without purification. MS: ESI (positive): 290 (M+H).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732618B2uspto-grants-2010_06