Reaktion #43805

Reaktionsgleichung

product

[2-Amino-4-(4-fluoro-benzenesulfonylamino)-phenylamino]-acetic acid tert-butyl ester

butyraldehyde

→

crude sub-title compound

[5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was cooled to ambient temperature
2. 2
   Einengenconcentrated under reduced pressure

Vorschrift

The product from step c.) (100 mg, 0.25 mmol) was dissolved in ethanol (5 mL) and treated with acetic acid (2 drops) followed by butyraldehyde (35 uL, 0.39 mmol). The reaction was heated to 70° C. for 18 hours. The reaction mixture was cooled to ambient temperature and concentrated under reduced pressure to give the crude sub-title compound that was used without further purification.

Quelle