Reaktion #437844

Reaktionsgleichung

1-chloromethyl-3-methyl-isoquinoline

3-chloroperoxybenzoic acid

→

1-Chloromethyl-3-methyl-isoquinoline-2-oxide

Lösungsmittel

methylene chloride

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with saturated sodium hydrogen carbonate solution
2. 2
   TrocknenThe combined organic phases are dried over magnesium sulphate
3. 3
   Sonstigeevaporated down
4. 4
   SonstigeThe solid, yellowish crude product is triturated with tert.-butylmethylether, suction
5. 5
   Filtrationfiltered
6. 6
   Waschenwashed with tert.-butylmethylether
7. 7
   Sonstigedried

Vorschrift

A solution of 300 mg of 1-chloromethyl-3-methyl-isoquinoline in 3 ml of methylene chloride is combined with 390 mg of 3-chloroperoxybenzoic acid and stirred overnight at ambient temperature. The reaction mixture is diluted with some methylene chloride and extracted with saturated sodium hydrogen carbonate solution. The combined organic phases are dried over magnesium sulphate and evaporated down. The solid, yellowish crude product is triturated with tert.-butylmethylether, suction filtered, washed with tert.-butylmethylether and dried.

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