Reaktion #4376

Reaktionsgleichung

3-methoxybenzeneacetic acid

iodine monochloride

water

→

2-iodo-5-methoxybenzeneacetic acid

Ausbeute 65.0%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solid collected
2. 2
   SonstigeIt was recrystallized from toluene

Vorschrift

A solution of 45 g (0.27 mole) of 3-methoxybenzeneacetic acid, 52.6 g (0.32 mole) of iodine monochloride and 1 g of iodine was allowed to stand in 500 ml of glacial acetic acid for six days at room temperature. The reaction was poured into water and the solid collected. It was recrystallized from toluene to give 51 g of crystalline 2-iodo-5-methoxybenzeneacetic acid, mp 133.5°-134.5° C. (65% yield).

Quelle