Reaktion #43738

Reaktionsgleichung

6-nitrobenzofuran-2-carboxylic acid

(R)-3-aminoquinuclidine dihydrochloride

HATU

N,N-diisopropylethylamine

→

title compound

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-6-nitro-1-benzofuran-2-carboxamide

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeDMF is removed under reduced pressure
2. 2
   Extraktionextracted three times with in each case 50 ml of ethyl acetate
3. 3
   TrocknenThe combined organic phases are dried over magnesium sulfate
4. 4
   Sonstigethe solvent is removed under reduced pressure
5. 5
   Sonstigea rotary evaporator
6. 6
   WaschenThe loaded ion exchange is washed six times with in each case 100 ml of methanol
7. 7
   WaschenThe product is then eluted with methanol/triethylamine 99:1 to 90:10
8. 8
   SonstigeThe solvent is removed under reduced pressure
9. 9
   TrocknenThe product is dried over magnesium sulfate

Vorschrift

1040 mg (5.02 mmol) of 6-nitrobenzofuran-2-carboxylic acid, 1000 mg (5.02 mmol) of (R)-3-aminoquinuclidine dihydrochloride, 2290 mg (6.03 mmol) of HATU, 2250 mg (18.08 mmol) of N,N-diisopropylethylamine and 15 ml of DMF are reacted according to the general procedure (variant B). DMF is removed under reduced pressure. The product is taken up in 100 ml of 1N aqueous sodium hydroxide solution and extracted three times with in each case 50 ml of ethyl acetate. The combined organic phases are dried over magnesium sulfate and the solvent is removed under reduced pressure using a rotary evaporator. The reaction mixture is taken up in methanol and, together with acidic ion exchange resin (Dowex WX2-200), stirred for about 40 min. The loaded ion exchange is washed six times with in each case 100 ml of methanol. The product is then eluted with methanol/triethylamine 99:1 to 90:10. The solvent is removed under reduced pressure. The product is dried over magnesium sulfate. 1.75 g (99% of theory) of the title compound are isolated.

Quelle