Reaktion #436213

Reaktionsgleichung

methyl quinoline-7-carboxylate

→

methyl 1,2,3,4-tetrahydroquinoline-7-carboxylate

Ausbeute 98.8%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered through diatomaceous earth
2. 2
   Einengenconcentrated under reduced pressure

Vorschrift

A solution of methyl quinoline-7-carboxylate (185 mg, 1.0 mmol) and PtO2 (20 mg) in methanol (10 mL) was shaken under an atmosphere of hydrogen for 2 h. The reaction mixture was filtered through diatomaceous earth, and concentrated under reduced pressure to provide methyl 1,2,3,4-tetrahydroquinoline-7-carboxylate (189 mg): ESI MS m/z 192 [M+H]+.

Quelle