Reaktion #436027

Reaktionsgleichung

Methyl 3-methyl-5-(3-thienyl)benzoate

lithium hydroxide

→

title compound

3-Methyl-5-(3-thienyl)benzoic acid

Lösungsmittel

tetrahydrofuran methanol water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated

Vorschrift

Methyl 3-methyl-5-(3-thienyl)benzoate (257 mg, 1.1 mmol) is treated with lithium hydroxide (186 mg, 4.4 mmol) in tetrahydrofuran/methanol/water (8 ml, 2:1:1) and the mixture is stirred for 2 hours at 20–25 degrees C. The mixture is acidified and concentrated to give the title compound, MS [M+H]+=217.0.

Quelle