Reaktion #435921

Reaktionsgleichung

diethylazodicarboxylate toluene

compound

2-hydroxymethyl-6-(3-dipropylaminopropyl)naphthalene

triphenylphosphine

phthalimide

→

compound

Ausbeute 67.7%

2-phthalimidomethyl-6-(3-dipropylaminopropyl)naphthalene

Ausbeute 67.7%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter completion of the reaction
2. 2
   workup.DISTILLATIONthe solvent was distilled off
3. 3
   Sonstigethe residue was then purified through silica gel column chromatography (hexane/ethyl acetate)

Vorschrift

The compound (453 mg) obtained in Example 121-9 was added with triphenylphosphine (516 mg) and phthalimide (245 mg), and then dissolved in anhydrous THF (10 ml). The solution was added with a 40% diethylazodicarboxylate/toluene solution (0.892 ml) in an ice bath and stirred at room temperature for 2 hours under a nitrogen atmosphere. After completion of the reaction, the solvent was distilled off and the residue was then purified through silica gel column chromatography (hexane/ethyl acetate), thereby obtaining the subject compound (439 mg) as a white solid.

Quelle