Reaktion #43587

Reaktionsgleichung

4-[(4-amino-1-piperidinyl)methyl]-3-chloro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one

8-fluoro-2,3-dihydro-1,4-benzodioxin-6-carboxaldehyde

→

title compound

Ausbeute 56.0%

3-Chloro-4-[(4-{[(8-fluoro-2,3-dihydro-1,4-benzodioxin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one Hydrochloride

Ausbeute 56.0%

Reaktionsbedingungen

Vorschrift

The free base of the title compound was prepared from 4-[(4-amino-1-piperidinyl)methyl]-3-chloro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one (32 mg) and 8-fluoro-2,3-dihydro-1,4-benzodioxin-6-carboxaldehyde (18.2 mg) according to the general method of Example 2(h) in 56% yield.

Quelle