Reaktion #435868

Reaktionsgleichung

compound

cyclohexyl-[4-(4-{[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)amino]methyl}benzylamino)benzyl]carbamic acid benzyl ester

methanol

hydrogen

→

N-(4-cyclohexylaminomethylphenyl)-4-{[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzamide

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter having been cooled with ice
2. 2
   SonstigeAfter the reaction
3. 3
   Filtrationthe solution was filtrated through Celite
4. 4
   workup.DISTILLATIONthe solvent was then distilled off
5. 5
   SonstigeThen, the residue was purified through silica gel column chromatography (chloroform/methanol)
6. 6
   workup.ADDITIONtreated with hydrochloric acid

Vorschrift

The compound (212 mg) obtained in Example 87-5 was dissolved in methanol (10 ml). After having been cooled with ice, the solution was added with a suspension of 10% palladium-carbon (105 mg) in ethanol (3.0 ml). After having been subjected to hydrogen displacement, the mixture was stirred under a hydrogen atmosphere at room temperature for 3 hours. After the reaction, the solution was filtrated through Celite and the solvent was then distilled off. Then, the residue was purified through silica gel column chromatography (chloroform/methanol) and treated with hydrochloric acid, thereby obtaining hydrochloride (43.1 mg) of the subject compound as a white solid.

Quelle