Reaktion #435863

Reaktionsgleichung

compound

N-(4-dipropylaminomethylphenyl)-4-{[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzamide

N,N-dimethylcarbamoyl chloride

→

compound

Ausbeute 42.0%

2-({[4-(4-dipropylaminomethylphenylcarbamoyl)-benzyl]-(1-methyl-1H-imidazol-2-ylmethyl)-amino}-methyl)-imidazol-1-carboxylic acid dimethylamide

Ausbeute 42.0%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONpyridine was distilled off
2. 2
   workup.ADDITIONthe residue was then added with a saturated aqueous sodium bicarbonate solution
3. 3
   Extraktionextracted with chloroform
4. 4
   EinengenThe extract was concentrated
5. 5
   Sonstigepurified through column chromatography (chloroform/methanol)

Vorschrift

The compound (95.0 mg) obtained in Example 49-1 was dissolved in pyridine (5.0 ml) and added with N,N-dimethylcarbamoyl chloride (20.0 mg). After the solution had been stirred at room temperature for 15 hours, pyridine was distilled off and the residue was then added with a saturated aqueous sodium bicarbonate solution and extracted with chloroform. The extract was concentrated and purified through column chromatography (chloroform/methanol), thereby obtaining the subject compound (45.4 mg) as a white solid.

Quelle