Reaktion #435789

Reaktionsgleichung

compound

2-benzylisoindole-1,3-dione

chlorosulfuric acid

→

4-(1,3-dioxo-1,3-dihydroisoindol-2-ylmethyl)benzenesulfonylchloride

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling
2. 2
   Einengenconcentrated
3. 3
   Sonstigedried
4. 4
   workup.ADDITIONThe resultant was gradually added with phosphorus pentachloride (300 mg)
5. 5
   Temperaturheated to 80° C.
6. 6
   workup.STIRRINGby stirring for 4 hours

Vorschrift

The compound (330 mg) obtained in Example 24-1 was dissolved in chloroform and then added with chlorosulfuric acid (manufactured by Kishida Chemical Co., Ltd.) (0.177 ml) under ice-cooling. The solution was stirred at room temperature for 2 days, and then concentrated and dried. The resultant was gradually added with phosphorus pentachloride (300 mg) and then heated to 80° C., followed by stirring for 4 hours.

Quelle