Reaktion #435594

Reaktionsgleichung

3-ethyl-4-nitro-1H-pyrazole-5-carboxamide

2-bromoethyl methyl ether

cesium carbonate

→

title compound

3-Ethyl-2-(2-methoxyethyl)-4-nitropyrazole-5-carboxamide

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated under reduced pressure
2. 2
   Sonstigethe residue was partitioned between ethyl acetate (125 ml) and brine (100 ml)
3. 3
   SonstigeThe phases were separated
4. 4
   Trocknenthe organic layer was dried (Na2SO4)
5. 5
   Sonstigeevaporated under reduced pressure
6. 6
   SonstigeThe crude product was purified by column chromatography on silica gel
7. 7
   Sonstigeto afford

Vorschrift

A mixture of 3-ethyl-4-nitro-1H-pyrazole-5-carboxamide (WO, 9849166), (1.7 g, 8.8 mmol), 2-bromoethyl methyl ether (0.85 ml, 8.85 mmol) and cesium carbonate (2.9 g, 9.0 mmol) in N,N-dimethylformamide (20 ml) was stirred at room temperature for 20 hours. The reaction mixture was concentrated under reduced pressure and the residue was partitioned between ethyl acetate (125 ml) and brine (100 ml). The phases were separated, and the organic layer was dried (Na2SO4), and evaporated under reduced pressure. The crude product was purified by column chromatography on silica gel, using ethyl acetate:methanol (97:3) as eluant to afford the title compound of preparation 1, 831 mg,

Quelle