Reaktion #43535

Reaktionsgleichung

(S)—N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

acetic anhydride

→

linezolid

Lösungsmittel

ethylacetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONis slowly added at ambient temperature
2. 2
   FiltrationThe separated solid is filtered
3. 3
   Sonstigedried under reduced pressure at 50° C.

Vorschrift

To the mixture of (S)—N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine (10 gm) and ethylacetate (100 ml), acetic anhydride (10 ml) is slowly added at ambient temperature, then stirred at ambient temperature for 1 hour. The separated solid is filtered and dried under reduced pressure at 50° C. to give 9.5 gm of linezolid form III.

Quelle