Reaktion #43453

ord-e3a58dcf2305483fb1ac7a8f34b6cb49

Reaktionsgleichung

O=C(O)CC1=CC(=O)OC1=O
(2,5-dioxo-2,5-dihydro-3-furanyl)acetic acid
NN.O=S(=O)(O)O
hydrazine sulphate
→
O=C(O)Cc1cc(=O)[nH][nH]c1=O
solid
Ausbeute 85.4%
O=C(O)Cc1cc(=O)[nH][nH]c1=O
(3,6-Dioxo-1,2,3,6-tetrahydro-4-pyridazinyl)acetic acid
Ausbeute 85.4%

Edukte

O=C(O)CC1=CC(=O)OC1=O
(2,5-dioxo-2,5-dihydro-3-furanyl)acetic acid
NN.O=S(=O)(O)O
hydrazine sulphate

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturwas heated
  2. 2
    Temperaturto reflux for 4 hours
  3. 3
    FiltrationThe precipitate was filtered
  4. 4
    Waschenwashing with water
  5. 5
    SonstigeDrying in vacuo

Vorschrift

A mixture of (2,5-dioxo-2,5-dihydro-3-furanyl)acetic acid (9 g) and hydrazine sulphate (7.2 g) in water was heated to reflux for 4 hours then allowed to cool to ambient temperature. The precipitate was filtered, washing with water then acetone. Drying in vacuo afforded a white solid (8.04 g, 82%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732460B2uspto-grants-2010_06