Reaktion #43436

Reaktionsgleichung

{5-({[4-(methyloxy)phenyl]methyl}oxy)-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate

triethylsilane

trifluoroacetic acid

→

{5-Hydroxy-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate trifluoroacetate salt

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter 16 hours the mixture was evaporated
2. 2
   Sonstigetriturated with toluene/ethyl acetate (250 ml/5 ml)
3. 3
   Sonstigeaffording a white solid
4. 4
   Sonstigethat was isolated by filtration
5. 5
   Sonstigedried in vacuo (22.5 g)

Vorschrift

A solution of {5-({[4-(methyloxy)phenyl]methyl}oxy)-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate (26.3 g, 67 mmol) in dichloromethane (700 ml) was treated with triethylsilane (10 ml, 62.6 mmol)and trifluoroacetic acid (35 ml). After 16 hours the mixture was evaporated and triturated with toluene/ethyl acetate (250 ml/5 ml) affording a white solid that was isolated by filtration and dried in vacuo (22.5 g).

Quelle