Reaktion #43415

Reaktionsgleichung

3,8-difluoro-4-methylidene-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one

tert-butanol water

sodium sulphite

→

solid

Ausbeute 97.0%

3,8-Difluoro-4-hydroxy-4-(hydroxymethyl)-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one

Ausbeute 97.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONmix alpha (4.3 g) under argon
2. 2
   workup.STIRRINGAfter 10 minutes stirring the mixture
3. 3
   Extraktionwas extracted with 20% methanol in dichloromethane (3×300 ml)
4. 4
   TrocknenThe organic extracts were dried over magnesium sulphate
5. 5
   Sonstigeevaporated

Vorschrift

A solution of 3,8-difluoro-4-methylidene-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one (631 mg, 2.9 mmol) in tert-butanol/water (30 ml/30 ml) was treated with AD mix alpha (4.3 g) under argon. After 18 hours stirring the reaction mixture was treated with saturated sodium sulphite solution (30 ml). After 10 minutes stirring the mixture was extracted with 20% methanol in dichloromethane (3×300 ml). The organic extracts were dried over magnesium sulphate and evaporated affording a white solid (710 mg, 97%).

Quelle