Reaktion #4340

Reaktionsgleichung

chloroformic acid methyl ester

2-(2-methylthioethoxy)-phenylhydrazine

H2O

→

2-[2-(methylthioethoxy)-phenyl]-hydrazinecarboxylic acid methyl ester

Lösungsmittel

tetrahydrofuran

N-ethyldiisopropylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe mixture is repeatedly extracted with ethyl acetate
2. 2
   SonstigeAfter customary further processing, a solid is obtained
3. 3
   Sonstigethis is recrystallised from alcohol
4. 4
   Sonstigeto thus yield the compond of the formula

Vorschrift

5.6 ml of chloroformic acid methyl ester are added dropwise at 0° C. to 14.4 g of 2-(2-methylthioethoxy)-phenylhydrazine in 100 ml of tetrahydrofuran and 14 g of N-ethyldiisopropylamine. The reaction mixture is stirred at 20° C. for 2 hours; H2O is then added, and the mixture is repeatedly extracted with ethyl acetate. After customary further processing, a solid is obtained, and this is recrystallised from alcohol to thus yield the compond of the formula ##STR62## having a melting point of 92°-94° C.

Quelle