Reaktion #43372

ord-567678157c9e4668a470f15f1995b5e5

Reaktionsgleichung

Cc1cccc(CBr)c1C(=O)OC(C)(C)C
tert-butyl 2-bromomethyl-6-methylbenzoate
CC(C)(CO)CO
2,2-dimethylpropane-1,3-diol
Cc1cccc(COCCCO)c1C(=O)OC(C)(C)C
tert-butyl 2-(3-hydroxypropoxymethyl)-6-methylbenzoate
→
Cc1cccc(COCC(C)(C)CO)c1C(=O)OC(C)(C)C
tert-Butyl 2-(3-hydroxy-2,2-dimethylpropoxymethyl)-6-methylbenzoate

Edukte

Cc1cccc(CBr)c1C(=O)OC(C)(C)C
tert-butyl 2-bromomethyl-6-methylbenzoate
CC(C)(CO)CO
2,2-dimethylpropane-1,3-diol
Cc1cccc(COCCCO)c1C(=O)OC(C)(C)C
tert-butyl 2-(3-hydroxypropoxymethyl)-6-methylbenzoate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

tert-Butyl 2-(3-hydroxy-2,2-dimethylpropoxymethyl)-6-methylbenzoate is prepared from tert-butyl 2-bromomethyl-6-methylbenzoate and 2,2-dimethylpropane-1,3-diol in analogy to the synthesis of tert-butyl 2-(3-hydroxypropoxymethyl)-6-methylbenzoate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732471B2uspto-grants-2010_06