Reaktion #433681

Reaktionsgleichung

triphenylphosphine

3-methoxyphenyl isocyanate

3-chloro-6-hydrazinopyridazine

1,2-dibromo-1,1,2,2-tetrachloroethane

→

6-chloro-N-(3-methoxyphenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-amine

Lösungsmittel

acetonitrile

triethylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwith cooling in ice
2. 2
   workup.STIRRINGstirred at room temperature for 3 days
3. 3
   EinengenThen, the reaction solution was concentrated under reduced pressure
4. 4
   Sonstigepurified by a standard method

Vorschrift

A solution of 3-methoxyphenyl isocyanate and 3-chloro-6-hydrazinopyridazine in acetonitrile was stirred at room temperature for 30 minutes, and 1,2-dibromo-1,1,2,2-tetrachloroethane was added and the mixture was stirred at room temperature for further 2 hours. This reaction solution was combined with triethylamine and triphenylphosphine with cooling in ice, and stirred at room temperature for 3 days. Then, the reaction solution was concentrated under reduced pressure, purified by a standard method to obtain 6-chloro-N-(3-methoxyphenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-amine. Dat (F:276).

Quelle