Reaktion #433678

Reaktionsgleichung

(6-chloropyridazin-3-yl)hydrazine

4-nitrobenzoic acid

hydrochloride

THF

→

N′-(6-chloropyridazin-3-yl)-4-nitrobenzohydrazide

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe precipitate was collected by filtration
2. 2
   Waschenwashed with water and diethyl ether

Vorschrift

A mixture of (6-chloropyridazin-3-yl)hydrazine, 4-nitrobenzoic acid, WSCD hydrochloride and THF was stirred at room temperature for 2 hours. The reaction solution was combined with water, and the precipitate was collected by filtration, washed with water and diethyl ether to obtain N′-(6-chloropyridazin-3-yl)-4-nitrobenzohydrazide. To this, acetic acid was added, and the mixture was stirred at 110° C. for 2 hours, the reaction solution was concentrated under reduced pressure, and the resultant crude crystal was washed with ethanol to obtain 6-chloro-3-(4-nitrophenyl)-1,2,4-triazolo[4,3-b]pyridazine. Dat (F:276).

Quelle