Reaktion #43364

ord-649ebafba1b641aeb7be4a1cd45faf2a

Reaktionsgleichung

O=c1cccc[nH]1
2H-pyridin-2-one
O=c1cc(OCc2ccc(Cl)cn2)ccn1-c1ccc(OC[C@@H]2CCCN2)cc1
4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{[(2S)-2-pyrrolidinyl]methoxy}phenyl)-1H-pyridin-2-one
CCN1CCC[C@H]1COc1ccc(-n2ccc(OCc3ccc(Cl)cn3)cc2=O)cc1
title compound
CCN1CCC[C@H]1COc1ccc(-n2ccc(OCc3ccc(Cl)cn3)cc2=O)cc1
4-[(5-Chloro-2-pyridinyl)methoxy]-1-(4-{[(2S)-1-ethyl-2-pyrrolidinyl]-methoxy}phenyl)-1H-pyridin-2-one

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Example 123 was repeated except that 4-[(5-chloro-2-pyridinyl)methoxy]-1-4-{(3R)-3-pyrrolidinyl]oxy}phenyl)-2H-pyridin-2-one was replaced with 4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{[(2S)-2-pyrrolidinyl]methoxy}phenyl)-1H-pyridin-2-one, to provide the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732456B2uspto-grants-2010_06