Reaktion #43341

Reaktionsgleichung

2,2-Diethoxyethanol

cesium carbonate

DMF

5-bromo-2-chloropyrimidine

→

title compound

Ausbeute 94.2%

5-bromo-2-(2,2-diethoxyethoxy)pyrimidine

Ausbeute 94.2%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction liquid
2. 2
   Extraktionwas extracted with ethyl acetate
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   EinengenConcentrating the solvent under reduced pressure
5. 5
   Sonstigethe residue was purified on silica gel column chromatography (C-200; ethyl acetate:hexane=1:9-1:4)

Vorschrift

2,2-Diethoxyethanol (1.6 g) and cesium carbonate (5.8 g) were added to DMF solution (10 mL) of 5-bromo-2-chloropyrimidine (1.15 g), and stirred at room temperature for 12 hours. After addition of water, the reaction liquid was extracted with ethyl acetate and dried over anhydrous magnesium sulfate. Concentrating the solvent under reduced pressure, the residue was purified on silica gel column chromatography (C-200; ethyl acetate:hexane=1:9-1:4) to provide the title compound (1.63 g, 94%).

Quelle