Reaktion #43332

Reaktionsgleichung

Trifluoroacetic acid

4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one

→

title compound

Ausbeute 92.7%

4-[(E)-2-(4-hydroxyphenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl)-ethoxy]phenyl}-1H-pyridin-2-one

Ausbeute 92.7%

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter concentrating
2. 2
   Sonstigethe reaction liquid under reduced pressure, chloroform
3. 3
   workup.ADDITIONwas added to the reaction liquid which
4. 4
   Waschenthen was washed with aqueous sodium hydrogencarbonate solution
5. 5
   Trocknendried over anhydrous sodium sulfate
6. 6
   EinengenConcentrating the solvent under reduced pressure

Vorschrift

Trifluoroacetic acid (2 mL) was added to 4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one (120 mg, 0.26 mmol) and stirred at room temperature for 30 minutes. After concentrating the reaction liquid under reduced pressure, chloroform was added to the reaction liquid which then was washed with aqueous sodium hydrogencarbonate solution and dried over anhydrous sodium sulfate. Concentrating the solvent under reduced pressure, the title compound (97 mg, 92%) was obtained as a white solid.

Quelle