Reaktion #43331

ord-d1c244cae05843078c2731495c3f27ca

Reaktionsgleichung

O=c1cc(OCc2ccccc2)ccn1-c1ccc(O)cc1
4-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one
CC(C)(C)Oc1ccc(/C=C/c2ccn(-c3ccc(O)cc3)c(=O)c2)cc1
4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-(4-hydroxyphenyl)-1H-pyridin-2-one
→
CC(C)(C)Oc1ccc(/C=C/c2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1
title compound
CC(C)(C)Oc1ccc(/C=C/c2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1
4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]pheny}-1H-pyridin-2-one

Edukte

O=c1cc(OCc2ccccc2)ccn1-c1ccc(O)cc1
4-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one
CC(C)(C)Oc1ccc(/C=C/c2ccn(-c3ccc(O)cc3)c(=O)c2)cc1
4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-(4-hydroxyphenyl)-1H-pyridin-2-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Step (3) of Example 12 was repeated except that 4-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one was replaced with 4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-(4-hydroxyphenyl)-1H-pyridin-2-one, to provide the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732456B2uspto-grants-2010_06