Reaktion #43311

Reaktionsgleichung

4-Benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one

2-(dimethylamino)ethanol

triphenylphosphine

diethyl azodicarboxylate

→

title compound

Ausbeute 66.6%

4-benzyloxy-1-{4-[2-(dimethylamino)ethoxy]phenyl}-1H-pyridin-2-one

Ausbeute 66.6%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenConcentrating
2. 2
   Sonstigethe reaction liquid under reduced pressure
3. 3
   Sonstigethe resulting residue was purified on silica gel column chromatography (C-300, methanol: chloroform=1:20-1:10)

Vorschrift

4-Benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one (150 mg, 0.511 mmol), 2-(dimethylamino)ethanol (0.057 mL, 0.562 mmol), triphenylphosphine (269 mg, 1.02 mmols) and diethyl azodicarboxylate (0.163 mL, 1.02 mmols) were stirred overnight in THF (4 mL). Concentrating the reaction liquid under reduced pressure, the resulting residue was purified on silica gel column chromatography (C-300, methanol: chloroform=1:20-1:10) to provide the title compound (124 mg, 60%).

Quelle