Reaktion #43291

Reaktionsgleichung

ethyl acetate

Acetic acid 2-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-nitro-pyridin-3-yloxy]-ethyl ester

hydrazine hydrate

→

Acetic acid 2-(6-aminomethyl-2-nitropyridin-3-yloxy)-ethyl ester

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was removed at reduced pressure
2. 2
   Waschenwashed twice with water (100 mL), saturated brine
3. 3
   Trocknendried (Na2SO4)
4. 4
   Sonstigethe solvents removed under reduced pressure
5. 5
   SonstigeThis was used without further purification or characterization

Vorschrift

To a solution of 0.35 gm (0.97 mmol) of Acetic acid 2-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-nitro-pyridin-3-yloxy]-ethyl ester 97 in 5 mL of ethanol was added 0.051 mL (1.01 mmol) of hydrazine hydrate at room temperature. The reaction mixture was allowed to stir for 4 h. The mixture was then transferred with ethyl acetate and the solvent was removed at reduced pressure. The residue was taken up in CHCl3 (200 mL) and washed twice with water (100 mL), saturated brine, dried (Na2SO4), and the solvents removed under reduced pressure. This was used without further purification or characterization.

Quelle