Reaktion #43277

Reaktionsgleichung

tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate

1,1-difluoro-4-iodomethylcyclohexane

ethyl 4,4-difluoro-cyclohexanecarboxylate

iodide

1-benzyl-1H-pyrazole-3-ylamine

→

N-(1-benzyl-1H-pyrazol-3-yl)-3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)propionamide

Reaktionsbedingungen

Vorschrift

Analogously to Example 36 and Example 44, tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate, 1,1-difluoro-4-iodomethylcyclohexane (prepared from commercially available ethyl 4,4-difluoro-cyclohexanecarboxylate analogously to the synthesis of the iodide described in Example 40) and 1-benzyl-1H-pyrazole-3-ylamine give N-(1-benzyl-1H-pyrazol-3-yl)-3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)propionamide.

Quelle