Reaktion #432700

Reaktionsgleichung

1-(1-cyclopropyl-1-methoxy-3-butenyl)-4-fluorobenzene

3-chlorobenzeneperoxoic acid

→

[2-cyclopropyl-2-(4-fluorophenyl)-2-methoxyethyl]oxirane

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate was filtered off
2. 2
   Waschenthe filtrate was washed successively with a saturate sodium carbonate solution
3. 3
   SonstigeThe organic phase was dried
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated

Vorschrift

To a stirred mixture of 100.6 parts of 1-(1-cyclopropyl-1-methoxy-3-butenyl)-4-fluorobenzene and 238 parts of dichloromethane was added a solution of 101.5 parts of 3-chlorobenzeneperoxoic acid in 952 parts of dichloromethane (exothermic reaction after 30 minutes). The whole was stirred overnight at room temperature. The precipitate was filtered off and the filtrate was washed successively with a saturate sodium carbonate solution, a saturate sodium sulfite solution, a 5% sodium hydroxide solution and water. The organic phase was dried, filtered and evaporated, yielding 106 parts of [2-cyclopropyl-2-(4-fluorophenyl)-2-methoxyethyl]oxirane as a residue (intermediate 7).

Quelle