Reaktion #431875

Reaktionsgleichung

3-(5-methyloxazol-2-yl)-pyridine

iodomethane

→

product

1-methyl-3-(5-methyloxazol-2-yl)-pyridinium iodide

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe whole is heated
2. 2
   Temperaturunder reflux for 10 hours
3. 3
   TemperaturAfter cooling
4. 4
   Sonstigedecanting
5. 5
   workup.ADDITIONether is added
6. 6
   Filtrationafter filtering

Vorschrift

5 g of 3-(5-methyloxazol-2-yl)-pyridine prepared as indicated in Chimica Therap 4, 437 (1973) is dissolved in 50 cm3 of ethanol, 3 cm3 of iodomethane is added and the whole is heated under reflux for 10 hours. After cooling and decanting, ether is added, and after filtering, 8.68 g of product is obtained. M.p.=147°-148° C., after crystallization from ethanol.

Quelle