Reaktion #431741

Reaktionsgleichung

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

potassium carbonate

3-benzyloxypropyl bromide

→

4-amino-N-((1-(3-benzyloxypropyl)piperidin-4-yl)methyl)-5-chloro-2-methoxybenzamide

Ausbeute 98.4%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONtreated in the same manner as in Example 199

Vorschrift

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (6 g) as a starting compound, potassium carbonate (10.1 g) and 3-benzyloxypropyl bromide (4.45 g) were reacted and treated in the same manner as in Example 199 to give 7.1 g of 4-amino-N-((1-(3-benzyloxypropyl)piperidin-4-yl)methyl)-5-chloro-2-methoxybenzamide, m.p. 82°-83° C.

Quelle