Reaktion #43168

ord-aa87c917396a4bebad6e27eda062f5d9

Reaktionsgleichung

O=Cc1cccc(-c2ccnc(Cl)n2)c1
Intermediate 1
O=Cc1cccc(-c2ccnc(Cl)n2)c1
3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde
C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1
3-(R)Methyl-piperazine-1-carboxylic acid tert-butyl ester
→
CC1CN(C(=O)OC(C)(C)C)CCN1Cc1cccc(-c2ccnc(Cl)n2)c1
4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

Edukte

O=Cc1cccc(-c2ccnc(Cl)n2)c1
Intermediate 1
O=Cc1cccc(-c2ccnc(Cl)n2)c1
3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde
C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1
3-(R)Methyl-piperazine-1-carboxylic acid tert-butyl ester
—
403

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Intermediate 1 was coupled with 3-(R)Methyl-piperazine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 403.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732444B2uspto-grants-2010_06