Reaktion #43147

ord-2bd34075cc684e6fa94351af2d25ceae

Reaktionsgleichung

Clc1ccnc(Cl)n1
2,4 dichloropyrimidine
O=Cc1cc(B(O)O)ccc1F
3-formyl 4-fluorophenyl boronic acid
→
O=Cc1cc(-c2ccnc(Cl)n2)ccc1F
5-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzaldehyde

Edukte

Clc1ccnc(Cl)n1
2,4 dichloropyrimidine
O=Cc1cc(B(O)O)ccc1F
3-formyl 4-fluorophenyl boronic acid
—
237

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

2,4 dichloropyrimidine and 3-formyl 4-fluorophenyl boronic acid were coupled following procedure A. LC-MS showed the product was >95% pure and had the expected M+H+ of 237.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732444B2uspto-grants-2010_06