Reaktion #431467

ord-889b7fe02ea8447da5f95f61bfc79ede

Reaktionsgleichung

CC(C)(C)OC(=O)NCC1CCNCC1
4-(tert-Butoxycarbonylaminomethyl)piperidine
COc1ccc(C2OCCOC2CCCl)cc1
4-ethylenedioxy-4-(4-methoxyphenyl)butyl chloride
O=C([O-])[O-].[K+].[K+]
potassium carbonate
→
COc1ccc(C2OCCOC2CCN2CCC(CNC(=O)OC(C)(C)C)CC2)cc1
1-(4-ethylenedioxy-4-(4-methoxyphenyl)butyl)-4-(tert-butoxycarbonylaminomethyl)piperidine
Ausbeute 37.7%

Edukte

CC(C)(C)OC(=O)NCC1CCNCC1
4-(tert-Butoxycarbonylaminomethyl)piperidine
COc1ccc(C2OCCOC2CCCl)cc1
4-ethylenedioxy-4-(4-methoxyphenyl)butyl chloride
O=C([O-])[O-].[K+].[K+]
potassium carbonate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONtreated in the same manner as in Preparation Example 181

Vorschrift

4-(tert-Butoxycarbonylaminomethyl)piperidine (10.0 g) as a starting compound, 4-ethylenedioxy-4-(4-methoxyphenyl)butyl chloride (12.0 g) and potassium carbonate (19.3 g) were reacted and treated in the same manner as in Preparation Example 181 to give 7.65 g of 1-(4-ethylenedioxy-4-(4-methoxyphenyl)butyl)-4-(tert-butoxycarbonylaminomethyl)piperidine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05864039uspto-grants-1999_01