Reaktion #43137

Reaktionsgleichung

3-Fluoro-4-methoxy-benzaldehyde

ammonium acetate

nitromethane

→

expected product

2-Fluoro-1-methoxy-4-(2-nitro-vinyl)-benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was refluxed for 2 hours
2. 2
   SonstigeThe nitromethane was removed by rotary evaporation
3. 3
   Sonstigethe residue recrystallized from ethanol

Vorschrift

3-Fluoro-4-methoxy-benzaldehyde (10 g) was dissolved in 100 mL of nitromethane along with 5 g of ammonium acetate. The mixture was refluxed for 2 hours. The nitromethane was removed by rotary evaporation and the residue recrystallized from ethanol to give 7.6 g of the expected product. LC-MS showed the product had the expected M+H+ of 198.

Quelle