Reaktion #431322

ord-ecd96af63a604012ab7049c1634ef81b

Reaktionsgleichung

CCCCc1nc2cccc(C#N)c2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1
tert.butyl 4'-[(2-n-butyl-7-cyano-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate
O=C(O)C(F)(F)F
trifluoroacetic acid
→
CCCCc1nc2cccc(C#N)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1
4'-[(2-n-Butyl-7-cyano-benzimidazol-1-yl)-methyl]-biphenyl-2-carboxylic acid

Edukte

CCCCc1nc2cccc(C#N)c2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1
tert.butyl 4'-[(2-n-butyl-7-cyano-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate
O=C(O)C(F)(F)F
trifluoroacetic acid

Reagenzien

Keine

Lösungsmittel

ClCCl
methylene chloride

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared in analogous manner to Example 9 from tert.butyl 4'-[(2-n-butyl-7-cyano-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate and trifluoroacetic acid in methylene chloride.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05864043uspto-grants-1999_01