Reaktion #43107

ord-b7644fd9266247f490d5b0956ab4261b

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCCCC1CCNCc1cccc(-c2ccnc(Cl)n2)c1
Intermediate 57
CC(C)(C)OC(=O)N1CCCCC1CCNCc1cccc(-c2ccnc(Cl)n2)c1
2-{2-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester
CS(=O)(=O)Cl
methanesulfonyl chloride
→
CC(C)(C)OC(=O)N1CCCCC1CCN(Cc1cccc(-c2ccnc(Cl)n2)c1)S(C)(=O)=O
2-(2-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-methanesulfonyl-amino}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Edukte

CC(C)(C)OC(=O)N1CCCCC1CCNCc1cccc(-c2ccnc(Cl)n2)c1
Intermediate 57
CC(C)(C)OC(=O)N1CCCCC1CCNCc1cccc(-c2ccnc(Cl)n2)c1
2-{2-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester
CS(=O)(=O)Cl
methanesulfonyl chloride
—
509

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Intermediate 57 was coupled with methanesulfonyl chloride following procedure D. LC-MS showed the product had the expected M+H+ of 509.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732444B2uspto-grants-2010_06