Reaktion #43104

ord-cfdad71f24f1403c9b44c193f396ce5c

Reaktionsgleichung

O=Cc1cccc(-c2ccnc(Cl)n2)c1
Intermediate 1
O=Cc1cccc(-c2ccnc(Cl)n2)c1
3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde
CC(C)(C)OC(=O)N1CCC(CN)CC1
4-Aminomethyl-piperidine-1-carboxylic acid tert-butyl ester
→
CC(C)(C)OC(=O)N1CCC(CNCc2cccc(-c3ccnc(Cl)n3)c2)CC1
4-{[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester

Edukte

O=Cc1cccc(-c2ccnc(Cl)n2)c1
Intermediate 1
O=Cc1cccc(-c2ccnc(Cl)n2)c1
3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde
CC(C)(C)OC(=O)N1CCC(CN)CC1
4-Aminomethyl-piperidine-1-carboxylic acid tert-butyl ester
—
417

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Intermediate 1 was coupled with 4-Aminomethyl-piperidine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 417.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732444B2uspto-grants-2010_06