Reaktion #43098

ord-a146f58063bc4a95bb4d3243df62ae4d

Reaktionsgleichung

Clc1ccnc(Cl)n1
2,4 dichloropyrimidine
CCCOc1ccc(B(O)O)cc1
4-propoxyphenylboronic acid
→
CCCOc1ccc(-c2ccnc(Cl)n2)cc1
2-Chloro-4-(4-propoxy-phenyl)-pyrimidine

Edukte

Clc1ccnc(Cl)n1
2,4 dichloropyrimidine
CCCOc1ccc(B(O)O)cc1
4-propoxyphenylboronic acid
—
249

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

2,4 dichloropyrimidine was coupled with 4-propoxyphenylboronic acid following procedure A. LC-MS showed the product had the expected M+H+ of 249.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732444B2uspto-grants-2010_06