Reaktion #43096

ord-620cf817364c4fcca15ade9a01a438ba

Reaktionsgleichung

Clc1ccnc(Cl)n1
2,4 dichloropyrimidine
CC(C)Cc1ccc(B(O)O)cc1
4-isobutylphenylboronic acid
→
CC(C)Cc1ccc(-c2ccnc(Cl)n2)cc1
2-Chloro-4-(4-isobutyl-phenyl)-pyrimidine

Edukte

Clc1ccnc(Cl)n1
2,4 dichloropyrimidine
CC(C)Cc1ccc(B(O)O)cc1
4-isobutylphenylboronic acid
—
247

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

2,4 dichloropyrimidine was coupled with 4-isobutylphenylboronic acid following procedure A. LC-MS showed the product had the expected M+H+ of 247:

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732444B2uspto-grants-2010_06